Independent study demonstrates amyloid probability score accurately indicates amyloid pathology.

ABSTRACT:

Background

The amyloid probability score (APS) is the model read-out of the analytically validated mass spectrometry-based PrecivityAD^® blood test that incorporates the plasma Aβ42/40 ratio, ApoE proteotype, and age to identify the likelihood of brain amyloid plaques among cognitively impaired individuals being evaluated for Alzheimer's disease.

Purpose

This study aimed to provide additional independent evidence that the pre-established APS algorithm, along with its cutoff values, discriminates between amyloid positive and negative individuals.

Methods

The diagnostic performance of the PrecivityAD test was analyzed in a cohort of 200 nonrandomly selected Australian Imaging, Biomarker & Lifestyle Flagship Study of Aging (AIBL) study participants, who were ei

SUBMITTER: Fogelman I 

PROVIDER: S-EPMC10187729 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature