Role of Strong Localized vs Weak Distributed Interactions in Disordered Protein Phase Separation.

ABSTRACT: Interaction strength and localization are critical parameters controlling the single-chain and condensed-state properties of intrinsically disordered proteins (IDPs). Here, we decipher these relationships using coarse-grained heteropolymers comprised of hydrophobic (H) and polar (P) monomers as model IDPs. We systematically vary the fraction of P monomers X_P and employ two distinct particle-based models that include either strong localized attractions between only H-H pairs (HP model) or weak distributed attractions between both H-H and H-P pairs (HP+ model). To compare different sequences and models, we first carefully tune the attraction strength for all sequences to match the single-chain radius of gyration. Interestingly, we find that this procedure produces similar c

SUBMITTER: Rekhi S 

PROVIDER: S-EPMC10187732 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature