High-stability spherical lanthanide nanoclusters for magnetic resonance imaging.

ABSTRACT: High-nuclear lanthanide clusters have shown great potential for the administration of high-dose mononuclear gadolinium chelates in magnetic resonance imaging (MRI). The development of high-nuclear lanthanide clusters with excellent solubility and high stability in water or solution has been challenging and is very important for expanding the performance of MRI. We used N-methylbenzimidazole-2-methanol (HL) and LnCl₃·6H₂O to synthesize two spherical lanthanide clusters, Ln₃₂ (Ln = Ho, Ho₃₂; and Ln = Gd, Gd₃₂), which are highly stable in solution. The 24 ligands L^- are all distributed on the periphery of Ln₃₂ and tightly wrap the cluster core, ensuring that the cluster is stable. Notably, Ho₃₂ can

SUBMITTER: Wang HL 

PROVIDER: S-EPMC10187785 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature