The influence of liver transplantation on the interplay between gut microbiome and bile acid homeostasis in children with biliary atresia.

ABSTRACT:

Background

Biliary atresia (BA) causes neonatal cholestasis and rapidly progresses into cirrhosis if left untreated. Kasai portoenterostomy may delay cirrhosis. BA remains among the most common indications for liver transplantation (LT) during childhood. Liver function and gut microbiome are interconnected. Disturbed liver function and enterohepatic signaling influence microbial diversity. We, herein, investigate the impact of LT and reestablishment of bile flow on gut microbiome-bile acid homeostasis in children with BA before (pre, n = 10), 3 months (post3m, n = 12), 12 months (post12m, n = 9), and more than 24 months (post24 + m, n = 12) after LT.

Methods

We analyzed the intestinal microbiome of BA patients before and after LT by 16S-rRNA-sequencing and bioinformatics ana

SUBMITTER: Waldner B 

PROVIDER: S-EPMC10187839 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature