<i>linc-mipep</i> and <i>linc-wrb</i> encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells.

ABSTRACT: Thousands of long intergenic non-coding RNAs (lincRNAs) are transcribed throughout the vertebrate genome. A subset of lincRNAs enriched in developing brains have recently been found to contain cryptic open-reading frames and are speculated to encode micropeptides. However, systematic identification and functional assessment of these transcripts have been hindered by technical challenges caused by their small size. Here, we show that two putative lincRNAs (linc-mipep, also called lnc-rps25, and linc-wrb) encode micropeptides with homology to the vertebrate-specific chromatin architectural protein, Hmgn1, and demonstrate that they are required for development of vertebrate-specific brain cell types. Specifically, we show that NMDA receptor-mediated pathways are dysregula

SUBMITTER: Tornini VA 

PROVIDER: S-EPMC10188112 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature