Light-Activated Assembly of Connexon Nanopores in Synthetic Cells.

ABSTRACT: During developmental processes and wound healing, activation of living cells occurs with spatiotemporal precision and leads to rapid release of soluble molecular signals, allowing communication and coordination between neighbors. Nonliving systems capable of similar responsive release hold great promise for information transfer in materials and site-specific drug delivery. One nonliving system that offers a tunable platform for programming release is synthetic cells. Encased in a lipid bilayer structure, synthetic cells can be outfitted with molecular conduits that span the bilayer and lead to material exchange. While previous work expressing membrane pore proteins in synthetic cells demonstrated content exchange, user-defined control over release has remained elusive. In mammalian cells,

SUBMITTER: Sihorwala AZ 

PROVIDER: S-EPMC10188233 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature