Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy.

ABSTRACT:

Context

Graves disease (GD) is one of the most common autoimmune disorders. Recent literature has shown an immune response involving several different inflammatory related proteins in these patients.

Objective

This work aimed to characterize the kynurenine pathway, activated during interferon-γ (IFN-γ)-mediated inflammation and cellular (T-helper type 1 [Th1] type) immunity, in GD patients with and without thyroid eye disease (TED).

Methods

We analyzed 34 biomarkers by mass spectrometry in serum samples from 100 patients with GD (36 with TED) and 100 matched healthy controls. The analytes included 10 metabolites and 3 indices from the kynurenine pathway, 6 microbiota-derived metabolites, 10 B-vitamers, and 5 serum proteins reflecting inflammation and kidney function.<

SUBMITTER: Ueland HO 

PROVIDER: S-EPMC10188306 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature