Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel.

ABSTRACT: Engineering heterogeneous hydrogels with distinct phases at various lengths, which resemble biological tissues with high complexity, remains challenging by existing fabricating techniques that require complicated procedures and are often only applicable at bulk scales. Here, inspired by ubiquitous phase separation phenomena in biology, we present a one-step fabrication method based on aqueous phase separation to construct two-aqueous-phase gels that comprise multiple phases with distinct physicochemical properties. The gels fabricated by this approach exhibit enhanced interfacial mechanics compared with their counterparts obtained from conventional layer-by-layer methods. Moreover, two-aqueous-phase gels with programmable structures and tunable physicochemical properties can be convenientl

SUBMITTER: Chen F 

PROVIDER: S-EPMC10188440 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature