Posterior hippocampal CA2/3 volume is associated with autobiographical memory recall ability in lower performing individuals.

ABSTRACT: People vary substantially in their capacity to recall past experiences, known as autobiographical memories. Here we investigated whether the volumes of specific hippocampal subfields were associated with autobiographical memory retrieval ability. We manually segmented the full length of the two hippocampi in 201 healthy young adults into DG/CA4, CA2/3, CA1, subiculum, pre/parasubiculum and uncus, in the largest such manually segmented subfield sample yet reported. Across the group we found no evidence for an association between any subfield volume and autobiographical memory recall ability. However, when participants were assigned to lower and higher performing groups based on their memory recall scores, we found that bilateral CA2/3 volume was significantly and positively associated with

SUBMITTER: Clark IA 

PROVIDER: S-EPMC10188443 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature