Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment.

ABSTRACT: Indoxyl sulfate is a protein-bound uremic toxin synthesized from indole that cannot be efficiently removed by the hemodialysis method and thus becomes a key risk factor for the progression of chronic kidney disease. Here, we develop a non-dialysis treatment strategy to fabricate an ultramicroporous olefin-linked covalent organic framework with high crystallinity in a green and scalable fashion for selectively removing the indoxyl sulfate precursor (i.e., indole) from the intestine. Various analyses show that the resulting material exhibits excellent gastrointestinal fluid stability, high adsorption efficiency, and good biocompatibility. Notably, it realizes the efficient and selective removal of indole from the intestine and significantly attenuates serum indoxyl sulfate level in vivo. Mor

SUBMITTER: Wei J 

PROVIDER: S-EPMC10188479 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature