Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1⁺ non-immune cells in human spontaneous preterm labor.

ABSTRACT: The mechanisms that underlie the timing of labor in humans are largely unknown. In most pregnancies, labor is initiated at term (≥ 37 weeks gestation), but in a signifiicant number of women spontaneous labor occurs preterm and is associated with increased perinatal mortality and morbidity. The objective of this study was to characterize the cells at the maternal-fetal interface (MFI) in term and preterm pregnancies in both the laboring and non-laboring state in Black women, who have among the highest preterm birth rates in the U.S. Using mass cytometry to obtain high-dimensional single-cell resolution, we identified 31 cell populations at the MFI, including 25 immune cell types and six non-immune cell types. Among the immune cells, maternal PD1⁺ CD8 T cell subsets were less abun

SUBMITTER: Liu X 

PROVIDER: S-EPMC10188528 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature