The abscopal effect of anti-CD95 and radiotherapy in melanoma.

ABSTRACT:

Background

Radiotherapy (RT) is frequently adopted to control cancer cell proliferation, which is achieved by altering the tumor microenvironment (TME) and immunogenicity. Apoptosis of cancer cells is the major effect of radiation on tumor tissues. Fas/APO-1(CD95) receptors on the cell membrane are death receptors that can be activated by diverse factors, including radiation and integration with CD95L on CD8⁺ T cells. The abscopal effect is defined as tumor regression out of the local RT field, and it is produced through anti-tumor immunity. The immune response against the radiated tumor is characterized by the cross-presentation between antigen-presenting cells (APCs), which includes cytotoxic T cells (CTLs) and dendritic cells (DCs).

Methods

The effect of activa

SUBMITTER: Xu J 

PROVIDER: S-EPMC10188694 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature