Metabolomics profile and 10-year atherosclerotic cardiovascular disease (ASCVD) risk score.

ABSTRACT:

Background

The intermediate metabolites associated with the development of atherosclerotic cardiovascular disease (ASCVD) remain largely unknown. Thus, we conducted a large panel of metabolomics profiling to identify the new candidate metabolites that were associated with 10-year ASCVD risk.

Methods

Thirty acylcarnitines and twenty amino acids were measured in the fasting plasma of 1,102 randomly selected individuals using a targeted FIA-MS/MS approach. The 10-year ASCVD risk score was calculated based on 2013 ACC/AHA guidelines. Accordingly, the subjects were stratified into four groups: low-risk (n = 620), borderline-risk (n = 110), intermediate-risk (n = 225), and high-risk (n = 147). 10 factors comprising collinear metabolites were extracted f

SUBMITTER: Dehghanbanadaki H 

PROVIDER: S-EPMC10188945 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature