Analysis of T-cell alloantigen response via a direct pathway in kidney transplant recipients with donor-specific antibodies.

ABSTRACT: Donor-specific antibodies (DSAs) are the main cause of graft loss over time. The direct pathway of alloantigen recognition is important in the pathogenesis of acute rejection. Recent studies have suggested that the direct pathway also contributes to the pathogenesis of chronic injury. Nevertheless, there are no reports on T-cell alloantigen response via the direct pathway in kidney recipients with DSAs. We analyzed the T-cell alloantigen response via the direct pathway in kidney recipients with DSAs (DSA+) or without DSAs (DSA-). A mixed lymphocyte reaction assay was implemented to assess the direct pathway response. DSA+ patients showed significantly higher CD8⁺ and CD4⁺ T cell responses to donor cells than DSA- patients. Furthermore, proliferating CD4<

SUBMITTER: Iwahara N 

PROVIDER: S-EPMC10189043 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature