Lipopolysaccharide-induced immune stress negatively regulates broiler chicken growth via the COX-2-PGE₂-EP4 signaling pathway.

ABSTRACT:

Aims

Immune stress in broiler chickens is characterized by the development of persistent pro-inflammatory responses that contribute to degradation of production performance. However, the underlying mechanisms that cause growth inhibition of broilers with immune stress are not well defined.

Methods

A total of 252 1-day-old Arbor Acres(AA) broilers were randomly allocated to three groups with six replicates per group and 14 broilers per replicate. The three groups comprised a saline control group, an Lipopolysaccharide (LPS) (immune stress) group, and an LPS and celecoxib group corresponding to an immune stress group treated with a selective COX-2 inhibitor. Birds in LPS group and saline group were intraperitoneally injected with the same amount of LPS or saline from 14d of ag

SUBMITTER: Liu K 

PROVIDER: S-EPMC10189118 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature