New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine.

ABSTRACT: Over the past thirty years, the importance of chemokines and their seven-transmembrane G protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes, including host homeostasis and responses to disease. Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity. Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases, including cancer, immune and inflammatory diseases, and metabolic and neurological disorders, which render the system a focus of studies aiming to discover therapies and important biomarkers. The integrated view of chemok

SUBMITTER: Xu H 

PROVIDER: S-EPMC10189238 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature