Establishment of a New Model of Lumbar Intervertebral Disc Degeneration With Pathological Characteristics.

ABSTRACT:

Study design

A prospective study.

Objectives

Intervertebral disc degenerative disease is a common and frequently-occurring disease in adults and is the main cause of lower back pain. However, there is a lack of universal animal models to study disc degeneration.

Methods

Forty-two male New Zealand white rabbits aged 12 months were used in this study. We established an endplate ischemic disc degeneration model though surgical ligation of rabbit lumbar vertebral body segment arteries. Two weeks after surgery, 6 experimental animals were randomly selected for follow-up tests. First, ischemia and lumbar disc degeneration were confirmed using imaging techniques. Then, immunohistochemical staining was performed to observe the growth of the annulus fibrosus. Finally, quantita

SUBMITTER: Jin Y 

PROVIDER: S-EPMC10189319 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature