Immunotherapy with or without targeted therapy for metastatic upper tract urothelial carcinoma: case report and literature review.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have been proved having a better safety profile compared to platinum-based chemotherapy and have demonstrated encouraging anti-tumor therapeutic effects for patients with metastatic urothelial carcinoma (mUC). However, few studies have evaluated the efficacy of ICIs in patients with metastatic upper tract urothelial carcinoma (mUTUC).

Case reports

Case 1 was a 71-year-old male patient diagnosed with left renal pelvic carcinoma, accompanied by a metastasis to the second lumbar spine. As the patient became refractory to chemotherapy, four cycles of camrelizumab, one of the ICIs, were administered, which helped to control the metastases and extend the patient's progression-free survival to five months. Case 2 was an 88-year-old fem

SUBMITTER: Ni K 

PROVIDER: S-EPMC10189380 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature