Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets.

ABSTRACT: The exquisite specificity, natural biological functions, and favorable development properties of antibodies make them highly effective agents as drugs. Monoclonal antibodies are particularly strong as inhibitors of systemically accessible targets where trough-level concentrations can sustain full target occupancy. Yet beyond this pharmacologic wheelhouse, antibodies perform suboptimally for targets of high abundance and those not easily accessible from circulation. Fundamentally, this restraint on broader application is due largely to the stoichiometric nature of their activity-one drug molecule is generally able to inhibit a maximum of two target molecules at a time. Enzymes in contrast are able to catalytically turnover multiple substrates, making them a natural sub-stoichiometric soluti

SUBMITTER: Romei MG 

PROVIDER: S-EPMC10189407 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature