Tolerability, acceptability, and reproducibility of topical STAR particles in human subjects.

ABSTRACT: Topical delivery to treat dermatological disease is constrained by low skin permeability to most drugs due to the stratum corneum barrier. STAR particles containing microneedle protrusions can be topically applied on the skin to create micropores that dramatically increase skin permeability, even to water-soluble compounds and macromolecules. This study addresses the tolerability, acceptability, and reproducibility of STAR particles rubbed on the skin at multiple pressures and after multiple applications to human subjects. One-time STAR particle application at pressures between 40 and 80 kPa showed that skin microporation and erythema directly correlated with increased pressure, and 83% of subjects reported STAR particles to be comfortable at all pressures. Repeated application of STAR par

SUBMITTER: Kim Y 

PROVIDER: S-EPMC10189432 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature