The nonlinear association between red blood cell distribution width (RDW) and bortezomib-related peripheral neurotoxicity (PN): A retrospective cohort study.

ABSTRACT:

Background

Previous evidence on the association of red blood cell distribution width (RDW) with bortezomib-induced peripheral neuropathy (BIPN) is limited. As a result, in this single-center retrospective cohort analysis, the link between RDW and BIPN was investigated.

Methods

This study4 comprised 376 patients with primary multiple myeloma (MM) who attended the Department of Haematology at Guizhou Provincial People's Hospital between 2013 and 2021. RDW and the occurrence of BIPN were the exposure and outcome variables, respectively. Demographic characteristics, pharmacological agents, co-morbidities, and MM-related indicators were all included as covariates. To investigate the relationship between RDW and BIPN, binary logistic regression and two-piecewise linear regression

SUBMITTER: Ren Y 

PROVIDER: S-EPMC10189471 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature