Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice.

ABSTRACT:

Background

S100 calcium-binding protein A9 (S100A9) is a danger-associated molecular pattern molecule that mediates the inflammatory response. Inflammation is essential in aging-related cardiovascular diseases. However, less is known regarding the role of S100A9 in vascular aging.

Methods

S100A9 null mice were used to investigate the role of S100A9 in aging-related pathologies. Artery rings were used to measure the functional characteristics of vascular with a pressurized myograph. Telomere length, Sirtuin activity, oxidative stress, and endothelial nitric oxide synthetase (eNOS) activity were used to elevate vascular senescence. Intraperitoneal glucose tolerance (IPGTT) and insulin sensitivity test (IST) were employed to investigate the effects of S100A9 on insulin resistan

SUBMITTER: Zhao B 

PROVIDER: S-EPMC10189516 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature