Association of 5α-Reductase Inhibitor Prescription With Bladder Cancer Progression in Males in South Korea.

ABSTRACT:

Importance

The antiandrogenic effect of the 5α-reductase inhibitor (5-ARI) has been investigated for its role in preventing male-predominant cancers. Although 5-ARI has been widely associated with prostate cancer, its association with urothelial bladder cancer (BC), another cancer experienced predominantly by males, has been less explored.

Objective

To assess the association between 5-ARI prescription prior to BC diagnosis and reduced risk of BC progression.

Design, setting, and participants

This cohort study analyzed patient claims data from the Korean National Health Insurance Service database. The nationwide cohort included all male patients with BC diagnosis in this database from January 1, 2008, to December 31, 2019. Propensity score matching was conducted to bal

SUBMITTER: An MH 

PROVIDER: S-EPMC10189569 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature