Impact of Prostate Health Index Results for Prediction of Biopsy Grade Reclassification During Active Surveillance.

ABSTRACT:

Purpose

We assessed whether Prostate Health Index results improve prediction of grade reclassification for men on active surveillance.

Methods and materials

We identified men in Canary Prostate Active Surveillance Study with Grade Group 1 cancer. Outcome was grade reclassification to Grade Group 2+ cancer. We considered decision rules to maximize specificity with sensitivity set at 95%. We derived rules based on clinical data (R₁) vs clinical data+Prostate Health Index (R₃). We considered an "or"-logic rule combining clinical score and Prostate Health Index (R₄), and a "2-step" rule using clinical data followed by risk stratification based on Prostate Health Index (R₂). Rules were applied to a validation set, where values of R

SUBMITTER: Filson CP 

PROVIDER: S-EPMC10189606 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature