Scientific opinion on the tolerable upper intake level for vitamin B6.

ABSTRACT: Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the tolerable upper intake level (UL) for vitamin B6. Systematic reviews of the literature were conducted by a contractor. The relationship between excess vitamin B6 intakes and the development of peripheral neuropathy is well established and is the critical effect on which the UL is based. A lowest-observed-effect-level (LOAEL) could not be established based on human data. A reference point (RP) of 50 mg/day is identified by the Panel from a case-control study, supported by data from case reports and vigilance data. An uncertainty factor (UF) of 4 is applied to the RP to account for the inverse relationship between dose and time t

SUBMITTER: EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) 

PROVIDER: S-EPMC10189633 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature