Lipid metabolism marker CD36 is associated with ¹⁸FDG-PET/CT false negative lymph nodes in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Lymph node metastasis frequently occurs in head and neck squamous cell carcinoma (HNSCC) patients, and [¹⁸F] fluorodeoxyglucose positron emission tomography with computed tomography (¹⁸FDG-PET/CT) examination for lymph node metastasis could result in false negativity and delay following treatment. However, the mechanism and resolution for ¹⁸FDG-PET/CT false negatives remain unclear. Our study was aim to found biomarkers for false negativity and true positivity from a metabolic perspective.

Methods

Ninety-two patients diagnosed with HNSCC who underwent preoperative ¹⁸FDG-PET/CT and subsequent surgery in our institution were reviewed. Immunohistochemistry (IHC) examinations of glucose metabolism (GLUT1 and GLUT5), amino ac

SUBMITTER: Meng X 

PROVIDER: S-EPMC10189774 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature