Design and 3D Printing of Personalized Hybrid and Gradient Structures for Critical Size Bone Defects.

ABSTRACT: Treating critical-size bone defects with autografts, allografts, or standardized implants is challenging since the healing of the defect area necessitates patient-specific grafts with mechanically and physiologically relevant structures. Three-dimensional (3D) printing using computer-aided design (CAD) is a promising approach for bone tissue engineering applications by producing constructs with customized designs and biomechanical compositions. In this study, we propose 3D printing of personalized and implantable hybrid active scaffolds with a unique architecture and biomaterial composition for critical-size bone defects. The proposed 3D hybrid construct was designed to have a gradient cell-laden poly(ethylene glycol) (PEG) hydrogel, which was surrounded by a porous polycaprolactone (PCL)

SUBMITTER: Altunbek M 

PROVIDER: S-EPMC10189796 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature