<i>APOL1</i> and the risk of adverse renal outcomes in patients of African ancestry with systemic lupus erythematosus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) disproportionately affects individuals of African ancestry (AA) compared to European ancestry (EA). In the general population, high risk (HR) variants in the apolipoprotein L1 (APOL1) gene increase the risk of renal and hypertensive disorders in individuals of AA. Since SLE is characterized by an interferon signature and APOL1 expression is driven by interferon, we examined the hypothesis that APOL1 HR genotypes predominantly drive higher rates of renal and hypertensive-related comorbidities observed in SLE patients of AA versus those of EA.

Methods

We performed a retrospective cohort study in patients with SLE of EA and AA using a genetic biobank linked to de-identified electronic health records. APOL1

SUBMITTER: Chung CP 

PROVIDER: S-EPMC10189827 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature