Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma.

ABSTRACT: Tumor budding (TB) has become a crucial factor for predicting the malignancy grade and prognostic outcome for multiple types of solid cancer. Studies have investigated the prognostic value of TB in hepatocellular carcinoma (HCC). However, its molecular mechanism in HCC remains unclear. To the best of our knowledge, the present study was the first to compare the expression of differentially expressed genes (DEGs) between TB-positive (TB-pos) and TB-negative HCC tissues. In the present study, total RNA was extracted from 40 HCC tissue specimens and then sequenced. According to Gene Ontology (GO) functional annotation, upregulated DEGs were markedly associated with embryonic kidney development-related GO terms, which suggested that the TB process may at least partly mimic the process of embry

SUBMITTER: Jiang D 

PROVIDER: S-EPMC10189853 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature