Rational design and topochemical synthesis of polymorphs of a polymer.

ABSTRACT: Packing a polymer in different ways can give polymorphs of the polymer having different properties. β-Turn forming peptides such as 2-aminoisobutyric acid (Aib)-rich peptides adopt several conformations by varying the dihedral angles. Aiming at this, a β-turn-forming peptide monomer would give different polymorphs and these polymorphs upon topochemical polymerization would yield polymorphs of the polymer, we designed an Aib-rich monomer N₃-(Aib)₃-NHCH₂-C[triple bond, length as m-dash]CH. This monomer crystallizes as two polymorphs and one hydrate. In all forms, the peptide adopts β-turn conformations and arranges in a head-to-tail manner with their azide and alkyne units proximally placed in a ready-to-react alignment. On heating, both the polymorphs underg

SUBMITTER: Athiyarath V 

PROVIDER: S-EPMC10189859 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature