CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1⁺ cells activate hepatocytic progenitor cell growth in rat liver regeneration.

ABSTRACT:

Background

Small hepatocyte-like progenitor cells (SHPCs) are hepatocytic progenitor cells that transiently form clusters in rat livers treated with retrorsine (Ret) that underwent 70% partial hepatectomy (PH). We previously reported that transplantation of Thy1⁺ cells obtained from D-galactosamine-treated livers promotes SHPC expansion, thereby accelerating liver regeneration. Extracellular vesicles (EVs) secreted by Thy1⁺ cells induce sinusoidal endothelial cells (SECs) and Kupffer cells (KCs) to secrete IL17B and IL25, respectively, thereby activating SHPCs through IL17 receptor B (RB) signaling. This study aimed to identify the inducers of IL17RB signaling and growth factors for SHPC proliferation in EVs secreted by Thy1⁺ cells (Thy1-EVs).

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SUBMITTER: Ichinohe N 

PROVIDER: S-EPMC10190025 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature