Identification of the Main Chemical constituents and mechanism of Renshen Guben oral liquid against Renal Fibrosis.

ABSTRACT:

Background

Renal fibrosis is the late stage of many chronic kidney diseases (CKD). Clinically, there is almost no effective treatment for renal fibrosis except dialysis. Renshen Guben oral liquid (RSGB) is a Chinese patent medicine approved by National Medical Products Administration (NMPA), which is suitable for clinical patients with chronic nephritis. Currently, the chemical constituents of RSGB remains unclear, and its efficacy and mechanism on renal fibrosis have not been reported.

Methods

In our research, ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) was employed to describe the chemical profile of RSGB, unilateral ureteral obstruction (UUO) model in mice was established to evaluate the beneficial effect of R

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10190030 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature