M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2⁺ Macrophage Subpopulations to Favor Post-AMI Cardiac Repair.

ABSTRACT: Tissue-resident cardiac macrophage subsets mediate cardiac tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)-expressing macrophages have phenotypical similarities to M1-polarized macrophages, are pro-inflammatory, and recruit CCR2⁺ circulating monocytes to infarcted myocardium. Small extracellular vesicles (sEV) from CCR2^̶ macrophages, which phenotypically resemble M2-polarized macrophages, promote anti-inflammatory activity and cardiac repair. Here, the authors harvested M2 macrophage-derived sEV (M2_EV ) from M2-polarized bone-marrow-derived macrophages for intramyocardial injection and recapitulation of sEV-mediated anti-inflammatory activity in ischemic-reperfusion (I/R) injured hearts. Rats and pigs r

SUBMITTER: Li L 

PROVIDER: S-EPMC10190454 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature