Rationally designed modular drug delivery platform based on intracellular peptide self-assembly.

ABSTRACT: Modulated molecular design-based intracellular self-assembly strategy has showed great potentiality in drug delivery, due to its assembling nature-resulted optimized drug biodistribution and metabolism. The modular designing concept endows the delivery system multiple functions, such as, selectivity and universality to improve the pharmacokinetics of loaded drugs. However, the accurate controlling of the self-assembling process in desired site to achieve optimal drug delivery is posed great challenges toward rational molecular design. Here, we fabricated a modulated drug-delivery system (MDS) through intracellular peptide self-assembly to realize effective drug delivery. MDS was designed based on modulated molecular designing strategy which contains five functional motifs and effectively t

SUBMITTER: An HW 

PROVIDER: S-EPMC10190849 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature