Manganese carbonate nanoparticles-mediated mitochondrial dysfunction for enhanced sonodynamic therapy.

ABSTRACT: Sonodynamic therapy (SDT) has attracted widespread attention due to its non-invasiveness and deep tissue penetration. However, the development of efficient sonodynamic nanoplatforms to improve the therapeutic efficiency is still one of the main challenges of current research. In this work, a new type of sonosensitizer prepared by a simple method, manganese carbonate nanoparticles (MnCO₃ NPs), is used for enhanced SDT. MnCO₃ NPs could generate large amounts of ¹O₂ and •OH under ultrasound irradiation. At the same time, CO₂ and Mn ions could be released in a weak acid environment due to the excellent degradability of MnCO₃ NPs. The CO₂ bubbles caused cell necrosis by ultrasonic cavitation and used for ultrasound ima

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10190974 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature