Gd₂O₃/b-TiO₂ composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy.

ABSTRACT: Photothermal therapy (PTT), as an important noninvasive and effective tumor treatment method, has been extensively developed into a powerful cancer therapeutic technique. Nevertheless, the low photothermal conversion efficiency and the limited tissue penetration of typical photothermal therapeutic agents in the first near-infrared (NIR-I) region (700-950 nm) are still the major barriers for further clinical application. Here, we proposed an organic/inorganic dual-PTT agent of synergistic property driven by polydopamine-modified black-titanium dioxide (b-TiO₂@PDA) with excellent photoconversion efficiency in the second NIR (NIR-II) region (1000-1500 nm). More specifically, the b-TiO₂ treated with sodium borohydride produced excessive oxygen vacancies resulting in oxyge

SUBMITTER: Chen J 

PROVIDER: S-EPMC10190978 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature