A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection.

ABSTRACT: Increasing bacterial drug resistance to antibiotics has posed a major threat to contemporary public health, which resulted in a large number of people suffering from serious infections and ending up dying without any effective therapies every year. Here, a dynamic covalent polymeric antimicrobial, based on phenylboronic acid (PBA)-installed micellar nanocarriers incorporating clinical vancomycin and curcumin, is developed to overcome drug-resistant bacterial infections. The formation of this antimicrobial is facilitated by reversible dynamic covalent interactions between PBA moieties in polymeric micelles and diols in vancomycin, which impart favorable stability in blood circulation and excellent acid-responsiveness in the infection microenvironment. Moreover, the structurally similar arom

SUBMITTER: Huang F 

PROVIDER: S-EPMC10191036 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature