SARS-CoV-2 omicron sub-lineages differentially modulate interferon response in human lung epithelial cells.

ABSTRACT: Although most of the attention was focused on the characterization of changes in the Spike protein among variants of SARS-CoV-2 virus, mutations outside the Spike region are likely to contribute to virus pathogenesis, virus adaptation and escape to the immune system. Phylogenetic analysis of SARS-CoV-2 Omicron strains reveals that several virus sub-lineages could be distinguished, from BA.1 up to BA.5. Regarding BA.1, BA.2 and BA.5, several mutations concern viral proteins with antagonistic activity to the innate immune system, such as NSP1 (S₁₃₅R), which is involved in mRNAs translation, exhibiting a general shutdown in cellular protein synthesis. Additionally, mutations and/or deletions in the ORF6 protein (D₆₁L) and in the nucleoprotein N (P₁₃L, D₃₁

SUBMITTER: Gori Savellini G 

PROVIDER: S-EPMC10191105 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature