Quantification of early gait development: Expanding the application of Catwalk technology to an infant rhesus macaque model.

ABSTRACT:

Background

Understanding gait development is essential for identifying motor impairments in neurodevelopmental disorders. Defining typical gait development in a rhesus macaque model is critical prior to characterizing abnormal gait. The goal of this study was to 1) explore the feasibility of using the Noldus Catwalk to assess gait in infant rhesus macaques and 2) provide preliminary normative data of gait development during the first month of life.

New method

The Noldus Catwalk was used to assess gait speed, dynamic and static paw measurements, and interlimb coordination in twelve infant rhesus macaques at 14, 21, and 28 days of age. All macaque runs were labeled as a diagonal or non-diagonal walking pattern.

Results

Infant rhesus macaques primarily used a diagonal (m

SUBMITTER: Kabakov SA 

PROVIDER: S-EPMC10191118 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature