Coronary Artery Calcium Density and Cardiovascular Events by Volume Level: The MESA.

ABSTRACT:

Background

The Agatston coronary artery calcium (CAC) score provides robust cardiovascular disease risk prediction but upweights plaque area by a density factor. Density, however, has been shown to be inversely associated with events. Using CAC volume and density separately improves risk prediction, but it is unclear how to apply this method clinically. We aimed to evaluate the association between CAC density and cardiovascular disease across the spectrum of CAC volume to better understand how to incorporate these metrics into a single score.

Methods

We performed an analysis of MESA (Multi-Ethnic Study of Atherosclerosis) participants with detectable CAC to evaluate the association between CAC density and events by level of CAC volume using multivariable Cox regression model

SUBMITTER: Bhatia HS 

PROVIDER: S-EPMC10191167 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature