Multiple sclerosis and breast cancer risk: a meta-analysis of observational and Mendelian randomization studies.

ABSTRACT:

Background

Several observational studies have explored the relationships between multiple sclerosis (MS) and breast cancer; however, whether an association exists remains unknown.

Methods

We conducted a meta-analysis of observational studies and Mendelian randomization (MR) based on genetic variants to identify the relationship between MS and breast cancer. The observational studies were searched from PubMed, Embase, Web of Science, and Scopus to assess the relationship between MS and breast cancer from inception to 07 Nov 2022. Moreover, we explored the association between genetically pre-disposed MS and breast cancer risk based on an MR study. The summary analysis for MS from two separate databases [International Multiple Sclerosis Genetics Consortium (IMSGC), FinnGen] and

SUBMITTER: Fang T 

PROVIDER: S-EPMC10191210 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature