Biologic targets of prescription medications and risk of neurodegenerative disease in United States Medicare beneficiaries.

ABSTRACT:

Objective

To identify prescription medications associated with a lower risk of three neurodegenerative diseases: Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis.

Methods

We conducted a population-based, case-control study of U.S. Medicare beneficiaries in 2009 (42,885 incident neurodegenerative disease cases, 334,387 randomly selected controls). Using medication data from 2006-2007, we categorized all filled medications according to their biological targets and mechanisms of action on those targets. We used multinomial logistic regression models, while accounting for demographics, indicators of smoking, and health care utilization, to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for 141 target-action pairs and each neurodegenerative d

SUBMITTER: Song Y 

PROVIDER: S-EPMC10191296 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature