Stereotactic Radiosurgery for Brain Metastases in Patients With a Heterozygous Germline Ataxia Telangiectasia Mutated Gene.

ABSTRACT: Germline mutations in the ataxia telangiectasia mutated (ATM) gene are associated with increased radiation sensitivity. Present literature lacks consensus on whether patients with heterozygous germline ATM mutations may be at greater risk of radiation-associated toxicities when treated with radiation therapy (RT), and there is little data considering more modern and conformal RT techniques such as stereotactic radiosurgery (SRS). Our report presents two cases of patients with heterozygous germline ATM mutations treated with SRS for brain metastases. One patient developed grade 3 radiation necrosis (RN) of an irradiated 16.3 cm³ resection cavity, but did not develop RN at other sites of punctate brain metastases treated with SRS. Similarly, the second report

SUBMITTER: Hall JC 

PROVIDER: S-EPMC10191388 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature