Th₁-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses.

ABSTRACT: Cytokines are regulators of the immune response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the contribution of cytokine-secreting CD4⁺ and CD8⁺ memory T cells to the SARS-CoV-2-specific humoral immune response in immunocompromised kidney patients is unknown. Here, we profiled 12 cytokines after stimulation of whole blood obtained 28 days post second 100 μg mRNA-1273 vaccination with peptides covering the SARS-CoV-2 spike (S)-protein from patients with chronic kidney disease (CKD) stage 4/5, on dialysis, kidney transplant recipients (KTR), and healthy controls. Unsupervised hierarchical clustering analysis revealed two distinct vaccine-induced cytokine profiles. The first profile was characterized by high levels of T-helper (Th)

SUBMITTER: den Hartog Y 

PROVIDER: S-EPMC10191401 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature