Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease.

ABSTRACT: In the past decade, single-cell technologies have proliferated and improved from their technically challenging beginnings to become common laboratory methods capable of determining the expression of thousands of genes in thousands of cells simultaneously. The field has progressed by taking the CNS as a primary research subject - the cellular complexity and multiplicity of neuronal cell types provide fertile ground for the increasing power of single-cell methods. Current single-cell RNA sequencing methods can quantify gene expression with sufficient accuracy to finely resolve even subtle differences between cell types and states, thus providing a great tool for studying the molecular and cellular repertoire of the CNS and its disorders. However, single-cell RNA sequencing requires the disso

SUBMITTER: Piwecka M 

PROVIDER: S-EPMC10191412 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature