A probiotic nanozyme hydrogel regulates vaginal microenvironment for Candida vaginitis therapy.

ABSTRACT: Molecular therapeutics are limited for Candida vaginitis because they damage normal cells and tissues of vagina, aggravating the imbalance of vaginal microbiota and increasing the recurrence. To tackle this limitation, through the combination of peroxidase-like rGO@FeS₂ nanozymes [reduced graphene oxide (rGO)] with Lactobacillus-produced lactic acid and H₂O₂, a responsive hyaluronic acid (HA) hydrogel rGO@FeS₂/Lactobacillus@HA (FeLab) is developed. FeLab has simultaneous anti-Candida albicans and vaginal microbiota-modulating activities. In particular, the hydroxyl radical produced from rGO@FeS₂ nanozymes and Lactobacillus kills C. albicans isolated from clinical specimens without affecting

SUBMITTER: Wei G 

PROVIDER: S-EPMC10191424 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature