Association of Fecal Calprotectin With Endoscopic and Histologic Activity in Pediatric Inflammatory Bowel Disease.

ABSTRACT: Fecal calprotectin (FC) is a noninvasive marker of intestinal inflammation used for screening and ongoing monitoring of inflammatory bowel disease (IBD); it is unclear the association of specific FC values with disease activity. The aim of our study was to examine the association of FC values with endoscopic and histologic severity.

Methods

We performed a retrospective chart review of patients who had FC done between 30 days and 1 day before colonoscopy at our institution. IBD patients were graded using the simple endoscopic score for Crohn's disease or Mayo endoscopic score for ulcerative colitis. Histologic slides were graded using the Geboes method.

Results

Three-hundred thirty-one patients were included in the study and 107 had IBD. For endoscopy, median FC was lowest for

SUBMITTER: Crawford E 

PROVIDER: S-EPMC10191562 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature