Dataset Information
Fetal death from SARS-CoV-2 mediated acute placental failure.
Ontology highlight
ABSTRACT: Introduction
We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure.Methods
Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.Results
Histologic changes in the placenta correlate with SARS-CoV-2 infection. Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2. Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant.Discussion
Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive. It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. Most of the cases described with fetal death occurred in the third trimester.
SUBMITTER: Kosic N
PROVIDER: S-EPMC10191722 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Publications
Fetal death from SARS-CoV-2 mediated acute placental failure.
Journal of reproductive immunology 20230518
<h4>Introduction</h4>We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure.<h4>Methods</h4>Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.<h4>Results</h4>Histologic changes in the placenta correlate with SARS-Co ...[more]
