Fetal death from SARS-CoV-2 mediated acute placental failure.

ABSTRACT:

Introduction

We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure.

Methods

Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.

Results

Histologic changes in the placenta correlate with SARS-CoV-2 infection. Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2. Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant.

Discussion

Several methods have been used to confirm SARS

SUBMITTER: Kosic N 

PROVIDER: S-EPMC10191722 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature