DeepBindPPI: Protein-Protein Binding Site Prediction Using Attention Based Graph Convolutional Network.

ABSTRACT: Due to the importance of protein-protein interactions in defence mechanism of living body, attempts were made to investigate its attributes, including, but not limited to, binding affinity, and binding region. Contemporary strategies for binding site prediction largely resort to deep learning techniques but turned out to be low precision models. As laboratory experiments for drug discovery tasks utilize this information, increased false positives devalue the computational methods. This emphasize the need to develop enhanced strategies. DeepBindPPI employs deep learning technique to predict the binding regions of proteins, particularly antigen-antibody interaction sites. The results obtained are applied in a docking environment to confirm their correctness. An integration of graph convoluti

SUBMITTER: Sunny S 

PROVIDER: S-EPMC10191823 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature