Glioblastoma remodelling of human neural circuits decreases survival.

ABSTRACT: Gliomas synaptically integrate into neural circuits^1,2. Previous research has demonstrated bidirectional interactions between neurons and glioma cells, with neuronal activity driving glioma growth^1-4 and gliomas increasing neuronal excitability^2,5-8. Here we sought to determine how glioma-induced neuronal changes influence neural circuits underlying cognition and whether these interactions influence patient survival. Using intracranial brain recordings during lexical retrieval language tasks in awake humans together with site-specific tumour tissue biopsies and cell biology experiments, we find that gliomas remodel functional neural circuitry such that task-relevant neural responses activate tumour-infiltrated cortex well beyond the cortical regions that ar

SUBMITTER: Krishna S 

PROVIDER: S-EPMC10191851 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature